Rallybio Announces Promising RLYB212 and RLYB332 Preclinical Data at the 66th American Society of Hematology Annual Meeting
RLYB 12.10.2024
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- 01.10.2025 - Rallybio Highlights 2024 Accomplishments and Anticipated Milestones for 2025
- 12.10.2024 - Rallybio Announces Promising RLYB212 and RLYB332 Preclinical Data at the 66th American Society of Hematology Annual Meeting
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“With our Phase 2 trial underway evaluating RLYB212 in pregnant women at higher risk of maternal alloimmunization and FNAIT, we are pleased that our collaborators at Versiti continue to add to the preclinical data showing RLYB212 has the potential to be a safe and effective preventative therapeutic using innovative nonclinical models,” said
In a poster titled“Prophylactic Administration of HPA-1a–Specific Antibody RLYB212 Safely Prevents Fetal/Neonatal Alloimmune Thrombocytopenia Due to HPA-1a Incompatibility in Pregnant Mice,”preclinical data was presented demonstrating that prophylactic administration of RLYB212 to pregnant mice at doses of 1.01 or 5.05 μg/kg prevented maternal alloimmunization. Further, pups born to RLYB212-treated, but not untreated, pregnant mice had normal platelet counts, demonstrating the ability of RLYB212 to prevent fetal and neonatal alloimmune thrombocytopenia (FNAIT). Data also showed that administration of RLYB212 did not cause thrombocytopenia in pups, supporting its safety as a prophylactic treatment.
In a poster titled“Long-Acting Anti-Matriptase-2 Antibody as a Potentially Best-in-Class Therapy for Iron Overload Diseases,”preclinical data was presented demonstrating that single intravenous injections of RLYB332 to humanized FcRn mice had rapid and sustained effects on pharmacodynamic (PD) parameters, including serum iron, unsaturated iron binding capacity (UIBC), and transferrin saturation (TSAT), and these effects were greater than those produced by comparator molecules. Additionally, treatment with RLYB332 was generally well-tolerated. These findings support RLYB332 as a potentially best-in-class therapeutic for the treatment of diseases of iron overload.
Poster presentation details:
Title:
Title:Long-Acting Anti-Matriptase-2 Antibody as a Potentially Best-in-Class Therapy for Iron Overload DiseasesPublication Number:3854Session
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Forward-Looking Statements
This press release contains forward-looking statements that are based on our management’s beliefs and assumptions and currently available information. All statements, other than statements of historical facts contained in this press release are forward-looking statements. In some cases, forward-looking statements can be identified by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements in this press release include, but are not limited to, statements concerning our expectations regarding future favorable clinical results based on RLYB212 and RLYB332 preclinical data, including our expectations regarding efficacy, safety, dosing, and administration, whether a monoclonal antibody inhibitor of matriptase-2 will be an effective treatment of diseases of iron overload, and the potential success of RLYB212 and RLYB332 for the diseases that we expect to treat. The forward-looking statements in this press release are only predictions and are based largely on management’s current expectations and projections about future events and financial trends that management believes may affect Rallybio’s business, financial condition and results of operations. These forward-looking statements speak only as of the date of this press release and are subject to a number of known and unknown risks, uncertainties and assumptions, including, but not limited to, our ability to successfully initiate and conduct our planned clinical trials, including the FNAIT natural history study, and a Phase 2 clinical trial for RLYB212, and complete such clinical trials and obtain results on our expected timelines, or at all, whether our cash resources will be sufficient to fund our operating expenses and capital expenditure requirements and whether we will be successful raising additional capital, our ability to enter into strategic partnerships or other arrangements, competition from other biotechnology and pharmaceutical companies, and those risks and uncertainties described in Rallybio’s filings with the
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