uniQure Announces Proposed Public Offering

QURE 01.07.2025

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LEXINGTON, Mass.andAMSTERDAM,Jan. 07, 2025(GLOBE NEWSWIRE) -- uniQure N.V. (Nasdaq: QURE), a leading gene therapy company advancing transformative therapies for patients with severe medical needs, today announced that it has commenced an underwritten public offering of its ordinary shares and pre-funded warrants to purchase its ordinary shares. All securities to be sold in the offering will be offered by uniQure. In addition, uniQure intends to grant the underwriters a 30-day option to purchase up to 15% additional ordinary shares at the public offering price, less underwriting discounts and commissions. The offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

Leerink Partnersis acting as the bookrunning manager for the proposed offering.

The securities described above are being offered by uniQure pursuant to its automatically effective shelf registration statement on Form S-3 filed with theU.S. Securities Exchange Commission(the “SEC”) onJanuary 7, 2025. A preliminary prospectus supplement and accompanying prospectus relating to the offering will be filed with theSECand will be available for free on the SEC’s website athttp://www.sec.gov. When available, copies of the preliminary prospectus supplement and the accompanying prospectus relating to the offering may be obtained fromLeerink Partners LLC, Attention:Syndicate Department,53 State Street, 40th Floor,Boston, Massachusetts02109, by telephone at +1 (800) 808-7525, ext. 6105, or by email atsyndicate@leerink.com. The final terms of the proposed offering will be disclosed in a final prospectus supplement to be filed with theSEC.

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or other jurisdiction. Any offer, if at all, will be made only by means of the prospectus supplement and accompanying prospectus forming a part of the effective registration statement.

About uniQure

uniQure is delivering on the promise of gene therapy – single treatments with potentially curative results. The approvals of uniQure’s gene therapy for hemophilia B – a historic achievement based on more than a decade of research and clinical development – represent a major milestone in the field of genomic medicine and ushers in a new treatment approach for patients living with hemophilia. uniQure is now advancing a pipeline of proprietary gene therapies for the treatment of patients withHuntington'sdisease, refractory temporal lobe epilepsy, ALS, Fabry disease, and other severe diseases.

Cautionary Note Regarding Forward-Looking Statements

This press release contains certain "forward-looking statements" within the meaning of the "safe harbor" provisions of the United States Private Securities Litigation Reform Act of 1995, including, without limitation, statements regarding the completion, timing, and size of uniQure’s anticipated public offering, the grant to the underwriters of an option to purchase additional securities, and other statements identified by words such as "estimate," "plan," "project," "forecast," "intend," "will," "shall," "expect," "anticipate," "believe," "seek," "target," "continue," "could," "may," "might," "possible," "potential," "predict" and similar words or expressions.

Forward-looking statements are based on management's beliefs and assumptions and on information available to management only as of the date of this press release. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: the uncertainties related to market conditions and the completion of the public offering on the anticipated terms, or at all, continued interest in our rare disease portfolio, the ability to develop our product candidates and technologies, the impact of changes in the financial markets and global economic conditions, and other factors described under the heading "Risk Factors" in uniQure’s periodic securities filings with theSEC, including our Annual Report on Form 10-K filed February 28, 2024, our Quarterly Report on Form 10-Q filed November 5, 2024, the preliminary prospectus supplement once filed with theSECand the accompanying prospectus, and other filings that uniQure makes with theSECfrom time to time. Given these risks, uncertainties, and other factors, you should not place undue reliance on these forward-looking statements, and uniQure assumes no obligation to update these forward-looking statements, even if new information becomes available in the future.

uniQure Contacts
For Investors:For Media:
Chiara RussoTom Malone
Direct: 617-306-9137Direct: 339-970-7758
Mobile: 617-306-9137Mobile: 339-223-8541
c.russo@uniQure.comt.malone@uniQure.com

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