Webcast scheduled forWednesday, November 6at11:30 a.m. Eastern Time

CARLSBAD, Calif.,Oct. 23, 2024/PRNewswire/ --Ionis Pharmaceuticals, Inc.(Nasdaq: IONS) announced today that it will host a live webcast onWednesday, November 6^that11:30 a.m. Eastern Timeto discuss its third quarter 2024 financial results.

The webcast may be accessed athttps://ir.ionis.com/events-and-presentations/upcoming-events. A replay will be available for a limited time at the same address.

AboutIonis Pharmaceuticals, Inc.For three decades, Ionis has invented medicines that bring better futures to people with serious diseases. Ionis currently has five marketed medicines and a leading pipeline in neurology, cardiology, and other areas of high patient need. As the pioneer in RNA-targeted medicines, Ionis continues to drive innovation in RNA therapies in addition to advancing new approaches in gene editing. A deep understanding of disease biology and industry-leading technology propels our work, coupled with a passion and urgency to deliver life-changing advances for patients. To learn more about Ionis, visitIonis.comand follow us onX (Twitter)andLinkedIn.

Ionis Pharmaceuticals Investor Contact:D. Wade Walke, Ph.D. –IR@ionis.com– 760-603-2331

Ionis Pharmaceuticals Media Contact:Hayley Soffer –media@ionis.com– 760-603-4679

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SOURCEIonis Pharmaceuticals, Inc.