Editas Medicine and Genevant Sciences to Collaborate to Develop Novel mRNA-LNP Gene Editing Therapeutics

EDIT 10.21.2024

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CAMBRIDGE, Mass.andVANCOUVER, British ColumbiaandBASEL, Switzerland,Oct. 21, 2024(GLOBE NEWSWIRE) --Editas Medicine, Inc. (Nasdaq: EDIT), a clinical-stage gene editing company, and Genevant Sciences, a leading nucleic acid delivery company with world-class platforms and a robust lipid nanoparticle (LNP) patent portfolio, today announced that they have entered into a collaboration and nonexclusive license agreement to combine Editas Medicine’s CRISPR Cas12a genome editing systems with Genevant’s proprietary LNP technology in the development ofin vivogene editing medicines directed to two undisclosed targets in Editas’ upregulation strategy.

“Editas has made significant strides to achieve our vision of becoming a leader inin vivoprogrammable gene editing medicine, and we are making strong progress towards the clinic as we develop our pipeline of future medicines,” saidLinda C. Burkly, Ph.D., Chief Scientific Officer,Editas Medicine. “As we investigated the delivery landscape to identify systems for ourin vivoupregulation strategy that would best complement our gene editing technology, we quickly identified Genevant, an established leader in the LNP space, and we are delighted to launch this collaboration.”

“We are thrilled to be working with Editas, a gene editing pioneer, to develop potentially transformative gene editing treatments,” saidJames Heyes, Chief Scientific Officer of Genevant Sciences. “LNPs have emerged as a preferred approach for delivering gene editing constructs, and we are excited by the promise of combining our industry-leading LNP technology with Editas’s innovation in this burgeoning field.”

Under the terms of the agreement, Genevant has granted to Editas a nonexclusive worldwide license under certain Genevant LNP technology to exploit mRNA-CRISPR Cas12a-LNP products directed to two undisclosed targets for specified fields. Genevant is eligible to receive up to$238 millionin upfront and contingent milestone payments, as well as tiered royalties on future product sales.

About Editas MedicineAs a clinical-stage gene editing company, Editas Medicine is focused on translating the power and potential of the CRISPR/Cas12a and CRISPR/Cas9 genome editing systems into a robust pipeline of treatments for people living with serious diseases around the world. Editas Medicine aims to discover, develop, manufacture, and commercialize transformative, durable, precision genomic medicines for a broad class of diseases. Editas Medicine is the exclusive licensee of Broad Institute’s Cas12a patent estate and Broad Institute and Harvard University’s Cas9 patent estates for human medicines. For the latest information and scientific presentations, please visitwww.editasmedicine.com.

About Genevant SciencesGenevant Sciences is a leading nucleic acid delivery company with world-class platforms, a robust lipid nanoparticle (LNP) patent portfolio, and decades of experience and expertise in nucleic acid drug delivery and development. Genevant’s scientists have pioneered LNP delivery of nucleic acids for over 20 years, and Genevant’s LNP platform, which has been studied across more than a dozen discrete product candidates and is the delivery technology behind the first and only approved systemic RNA-LNP product (patisiran), enables a wide array of RNA-based applications, including vaccines, therapeutic protein production, and gene editing. For more information, please visitwww.genevant.com.

Editas Medicine Forward-Looking StatementsThis press release contains forward-looking statements and information within the meaning of The Private Securities Litigation Reform Act of 1995. The words ‘‘anticipate,’’ ‘‘believe,’’ ‘‘continue,’’ ‘‘could,’’ ‘‘estimate,’’ ‘‘expect,’’ ‘‘intend,’’ ‘‘may,’’ ‘‘plan,’’ ‘‘potential,’’ ‘‘predict,’’ ‘‘project,’’ ‘‘target,’’ ‘‘should,’’ ‘‘would,’’ and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these identifying words. Forward-looking statements in this press release include statements regarding the expected benefits of Editas’ collaboration with Genevant, including the potential to generate medicines from the collaboration. Editas may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various important factors, including: uncertainties inherent in the initiation and completion of pre-clinical studies and clinical trials, and clinical development of Editas’ product candidates and availability of funding sufficient for Editas’ foreseeable and unforeseeable operating expenses and capital expenditure requirements. These and other risks are described in greater detail under the caption “Risk Factors” included in Editas’ most recent Annual Report on Form 10-K, which is on file with theSecurities and Exchange Commission, as updated by Editas’ subsequent filings with theSecurities and Exchange Commission, and in other filings that Editas may make with theSecurities and Exchange Commissionin the future. Any forward-looking statements contained in this press release speak only as of the date hereof, and Editas expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise.

This press release contains hyperlinks to information that is not deemed to be incorporated by reference in this press release.

Contacts:Editas MedicineCristi Barnett(617) 401-0113cristi.barnett@editasmed.comGenevant SciencesPete Zornpete.zorn@genevant.com

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Source: Editas Medicine, Inc.

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