Charles River Launches New Retrogenix® Non-Human Protein Library

CRL 10.17.2024

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First-in-class in vitro library assesses off-target binding to de-risk in vivo studies

WILMINGTON, Mass.--(BUSINESS WIRE)--Oct. 17, 2024--Charles River Laboratories International, Inc.(NYSE: CRL) today announced the launch of theRetrogenix®Non-Human Protein Library. The non-human protein library helps biopharmaceutical clients assess off-target binding to a non-human proteome to de-riskin vivostudies and aid in non-human species selection.

“Developed in-house using the innovative and unique Retrogenix®platform, the new library provides early insights into how therapeutics interact with non-human protein targetsin vitro,” saidAidan Synnott, Ph.D., Corporate Vice President, Global Discovery. “These early insights are generated without the lead time and expense associated withex vivotissue orin vivoresearch model studies, allowing clients to progress to safety studies, clinical trials, and IND applications with highly relevant data and increased confidence.”

Confirming whether potential off-targets are conserved across species increases the interpretability ofin vivoresults and ultimately reduces risk by ensuring safety studies are conducted in an appropriate model from the outset. In addition to offering the non-human protein library, Charles River can also screen observed human off-targets against any suitable non-human homologous proteins to help inform next steps for client drug development.

Screening for Off-Target EffectsThe Retrogenix®platformoffers the industry’s largest library of human proteins overexpressed in human cells, with over 6,500 human plasma membrane and secreted protein clones, providing a unique screening tool for discovering primary target receptors and reliably assessing potential off-target binding issues. With thenew non-human protein library, Charles River is building on the Retrogenix®platform’s established technology, helping clients ensure they have the right models selected prior to beginningin vivostudies, saving time and helping deliver safer, more effective drugs.

Off-target screening is an established part of the IND submission process, and is traditionally performed usingtissue cross reactivity (TCR) studies. Data from the Retrogenix®platform has become an established complementary or alternative data point across multiple modalities, therapeutic areas, and with international regulatory agencies.

Driving Innovation in the3RsDesignedin silicoand synthetically generated, the biosynthetic non-human protein library incorporates important tenants of the 3Rs—reduction and refinement—leveraging technological innovations to responsibly progress research.

“The integration of the Retrogenix®Non-Human Protein Libraryinto our drug discovery portfolio enhances the precision and effectiveness of lead candidate selection,” added ProfessorJulie Frearson, Ph.D., Corporate Senior Vice President & Chief Scientific Officer. “Technology is a cornerstone of innovation, and as we continue to drive forward change in drug development, these innovations allow us to refine our use of research models while supporting the discovery of novel medicines.”

Building on the imperative to deliver on the3Rs(Replacement, Reduction, and Refinement of research animals), Charles River launched theAlternative Methods Advancement Project(AMAP), with a dedicated pursuit of scientific and technological innovation and by aligning the Company’s strategic efforts with the focus needed to advance animal alternatives.

About theAlternative Methods Advancement Project(AMAP)TheAlternative Methods Advancement Project(AMAP) is a Charles River initiative dedicated to developing alternatives to reduce the use of animals in testing. As we enter the next frontier of drug development, AMAP will facilitate strategic and purposeful investing to lead the way toward a future where more patients receive needed treatments and medicines safely, swiftly, and successfully. In keeping with our commitment to the3Rs, we are dedicated to pursuing scientific and technological innovations to explore new and exciting ways we can further reduce the use of animals in testing. The guidance of AMAP will help us align our investments, partnerships, product and service initiatives, and advocacy efforts as we focus on our goal of investing$300 millionover the next five years to further enhance this critical mission and drive industry-wide adoption of alternatives.

About Charles RiverCharles River provides essential products and services to help pharmaceutical and biotechnology companies, government agencies and leading academic institutions around the globe accelerate their research and drug development efforts. Our dedicated employees are focused on providing clients with exactly what they need to improve and expedite the discovery, early-stage development and safe manufacture of new therapies for the patients who need them. To learn more about our unique portfolio and breadth of services, visitwww.criver.com.

View source version onbusinesswire.com:https://www.businesswire.com/news/home/20241017338853/en/

Investor:Todd SpencerCorporate Vice President,Investor Relations781.222.6455todd.spencer@crl.com

Media:Amy CianciarusoCorporate Vice President,Chief Communications Officer781.222.6168amy.cianciaruso@crl.com

Source:Charles River Laboratories International, Inc.

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